PozeSCAF® is an integrated preclinical drug discovery CRO and scientific partner advancing programs from target identification and validation through hit discovery, hit-to-lead, lead optimization, and candidate selection. Our proprietary AxDrug™ platform combines disease intelligence, generative AI, computational chemistry, and physics-based modeling with medicinal chemistry, synthesis, and in vitro biology—connecting molecular design with experimental validation in a rapid DMTA loop to deliver differentiated drug candidates faster.
AI-POWERED DRUG DISCOVERY, EXPERIMENTALLY VALIDATED
AI & Computational Drug Discovery
AxDrug™ combines disease and target intelligence with generative AI and large-scale virtual screening to identify and design promising molecules.
Physics-based modeling and molecular simulations evaluate binding, selectivity, and molecular behavior, while predictive biology anticipates ADMET, safety, and off-target effects.
Its target-agnostic platform adapts to diverse proteins, diseases, and modalities—accelerating the path from biological insight to experimentally validated candidates.
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Medicinal Chemistry & Synthesis
Our medicinal chemistry team transforms computational designs and biological insights into optimized, synthesis-ready molecules.
Retrosynthetic analysis and route design guide efficient synthesis, purification, and analytical characterization to confirm compound identity, purity, and quality.
Systematic SAR exploration connects structural changes with biological activity—improving potency, selectivity, and developability through every DMTA cycle.
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In Vitro Biology
Our in vitro biology team develops biochemical and cell-based assays tailored to each target, pathway, and disease context.
Target-engagement studies confirm direct molecular interaction, while functional pharmacology measures the resulting biological response, potency, and selectivity.
Experimental validation generates decision-ready data that guides SAR and feeds each DMTA cycle toward better drug candidates.
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DRUG DISCOVERY APPROACH
THERAPEUTIC MODALITIES
Connect with our team · 2026
Meet PozeSCAF
Meet us at upcoming industry events to discuss AI-enabled drug discovery, medicinal chemistry, synthesis and in vitro biology.
| Event | Dates · 2026 | Location |
|---|---|---|
| LSX Congress USA | – | Boston, USA |
| Discovery on Target | – | Boston, USA |
| BioJapan | – | Yokohama, Japan |
| Precision Drug Discovery, Preclinical & Manufacturing Summit | – | San Diego, USA |
| Covalent Drug Discovery & Development Summit | – | Boston, USA |
| Drug Discovery Chemistry Europe | – | Barcelona, Spain |
| US Biotech Day | – | Philadelphia, USA |
FEW OF OUR CLIENTS
