Your discovery partner
Your program.
Our integrated
expertise.
PozeSCAF is a preclinical drug discovery CRO and scientific partner supporting programs from target identification and validation through hit discovery, lead optimization, and candidate selection.
Engage us for a focused scientific challenge or an integrated discovery program—with computational scientists, medicinal chemists, and biologists working together around your objectives.
Three disciplines. One discovery team.
AI & Computational Drug Discovery
AxDrug™ combines disease and target intelligence, generative AI, and virtual screening to identify and prioritize chemical matter.
Physics-based modeling and molecular simulation guide design, while predictive models assess ADMET properties and potential off-target liabilities.
Explore AxDrug™ →Medicinal Chemistry & Synthesis
Structure-guided medicinal chemistry translates design hypotheses into compounds ready for experimental testing.
Our team develops synthetic routes, synthesizes and characterizes molecules, and builds structure–activity relationships to guide potency, selectivity, and developability.
Explore Medicinal Chemistry & Synthesis →In Vitro Biology
Target-specific biochemical and cell-based assays measure compound activity and biological response.
Target-engagement and functional studies help evaluate mechanism, potency, and selectivity—generating experimental feedback for the next design cycle.
Explore In Vitro Biology →Integrated discovery engine
AxDrug™ — Intelligence
Connected to Experiment
One connected workflow linking disease biology, generative design, molecular physics, predictive developability, and experimental feedback.
- 01
Understand
KG-SCAF
Disease biology
Target validation - 02
Design
Generative AI
Medicinal chemistry
Modality design - 03
Evaluate
Docking
MD · FEP
QM/MM - 04
Make
MedChem
Synthesis
Peptide chemistry - 05
Test
Biochemical
Cellular
ADME - 06
Learn
SAR
Active learning
Next DMTA cycle
THERAPEUTIC MODALITIES
DISCOVERY CHALLENGES WE ADDRESS
Complex targets.
Clear next experiments.
Connecting molecular insight with design decisions and experimental testing.
Find the hidden pocket.
Explore protein flexibility and transient pockets to guide molecular design, prioritize potential hits, and plan experimental testing.
Pocket exploration → Design → Testing
Design for selectivity.
Compare related binding environments and combine molecular modeling, medicinal chemistry, and experimental feedback to investigate differentiation.
Potency + Selectivity + Developability
Bring proteins together.
Explore ternary-complex geometry, linker design, and molecular interactions to guide proximity-driven strategies and functional testing.
Structure → Design → Functional testingFEW OF OUR CLIENTS
Connect with our team · 2026
Meet PozeSCAF
Meet us at upcoming industry events to discuss AI-enabled drug discovery, medicinal chemistry, synthesis and in vitro biology.
| Event | Dates · 2026 | Location |
|---|---|---|
| Discovery on Target | – | Boston, USA |
| BioJapan | – | Yokohama, Japan |
| Precision Drug Discovery, Preclinical & Manufacturing Summit | – | San Diego, USA |
| Covalent Drug Discovery & Development Summit | – | Boston, USA |
| Drug Discovery Chemistry Europe | – | Barcelona, Spain |
| US Biotech Day | – | Philadelphia, USA |