In Vitro Biology Services
Experimental Biology Integrated with AI-Driven Drug Discovery
PozeSCAF provides integrated in vitro biology services to support target identification, target validation, hit confirmation, compound prioritization, hit-to-lead, lead optimization, and clinical candidate nomination. Our biology workflows connect biochemical and cell-based evidence with AxDrug™, computational chemistry, and medicinal and synthetic chemistry to guide data-driven discovery decisions.
Our Core Biology Capabilities
Integrated Design–Make–Test–Analyze Workflow
Successful drug discovery depends on continuous collaboration between computational scientists, medicinal chemists, synthetic chemists, and biologists. At PozeSCAF, in vitro biology is integrated into every stage of the discovery process. Experimental data generated through biochemical and cell-based assays is continuously combined with computational predictions and medicinal chemistry insights to accelerate compound optimization and improve project decisions.
How Biology Supports Drug Discovery
Target Identification & Validation
Identify and validate biological targets and establish relevant experimental systems before compound evaluation.
Hit Confirmation
Confirm active compounds identified through AI-driven design, virtual screening, or external screening campaigns.
Hit-to-Lead
Prioritize promising compounds using biochemical and cell-based assay data to support lead selection.
Lead Optimization
Support iterative compound optimization through rapid experimental feedback integrated with medicinal chemistry.
Mechanism of Action
Investigate biological activity, pathway modulation, and functional responses to better understand compound behavior.
Decision Support
Generate experimental evidence that helps multidisciplinary teams make informed drug discovery decisions.
Therapeutic Area Experience
PozeSCAF supports drug discovery programs across multiple therapeutic areas through integrated biology, chemistry, and AI-driven discovery workflows. Our teams develop customized experimental strategies based on target biology, disease mechanisms, and program objectives.
Areas of Scientific Experience
- Oncology: Target validation, cell-based assays, mechanism-of-action studies, and lead optimization.
- Fibrosis: Experimental biology supporting anti-fibrotic drug discovery and pathway-focused research.
- Immunology & Inflammation: Biochemical and cellular assays for immune signaling and inflammatory pathways.
- Metabolic Disorders: Biology workflows supporting metabolic targets and transporter-related research.
- Ophthalmology: Disease-relevant biology supporting ocular drug discovery and translational research.
- Rare Disease: Mechanistic Biology Assays, Patient-Derived Models and Biomarker Discovery.
- Neurodegenerative Diseases: Neurodegenerative Disease Models & Mechanistic Biology.
- Longevity: Longevity Assays, Mitochondrial Health & Cellular Senescence.
Drug Discovery Modalities
We support drug discovery programs across multiple therapeutic modalities by integrating AI-driven molecular design, computational chemistry, medicinal chemistry, and in vitro biology to accelerate the discovery and optimization of novel therapeutics.
- Small Molecules: Discovery and optimization of orally available, cell-permeable therapeutics.
- Peptides – Design and optimization of highly selective peptide therapeutics.
- PROTACs & Molecular Glues – Discovery strategies for targeted protein degradation.
- Covalent Inhibitors – Rational design and optimization of irreversible and reversible covalent binders for challenging therapeutic targets.
Why Choose PozeSCAF Biology?
PozeSCAF delivers biology services designed to support real-world drug discovery programs. Our scientific teams focus on generating reliable experimental data, developing customized workflows, and collaborating closely with clients to accelerate discovery decisions from early validation through lead optimization.
Custom Assay Development
Develop and optimize assays tailored to specific biological targets, mechanisms, and research objectives.
Target-Specific Biology
Experimental workflows designed around the biology of individual targets and disease pathways.
Flexible Study Design
Adapt study designs, assay formats, controls, and endpoints to meet program-specific requirements.
Collaborative Scientific Support
Work directly with PozeSCAF scientists throughout project planning, execution, data review, and decision making.
Frequently Asked Questions
1. What are in vitro biology services?
In vitro biology services involve laboratory-based experiments performed outside a living organism to evaluate biological targets, characterize compound activity, investigate mechanisms of action, and support decision-making throughout drug discovery. These studies commonly include biochemical assays, cell-based assays, and advanced in vitro models.
2. What types of in vitro biology services does PozeSCAF provide?
PozeSCAF provides integrated in vitro biology services including biochemical assays, cell-based assays, and advanced in vitro models. Our multidisciplinary teams work closely with computational scientists and medicinal chemists to generate experimental data that supports target validation, hit confirmation, hit-to-lead, and lead optimization.
3. How are biology services integrated with AI-driven drug discovery?
Experimental biology data generated at PozeSCAF is integrated with AxDrug™, computational chemistry, medicinal chemistry, and synthetic chemistry. This design–make–test–analyze workflow enables continuous refinement of compounds based on experimental evidence and computational insights.
4. Can PozeSCAF develop customized biology workflows?
Yes. PozeSCAF develops customized biology workflows based on each client’s therapeutic area, biological target, mechanism of action, assay requirements, and project objectives. Our scientists work collaboratively with clients to design experimental strategies tailored to specific research programs.
5. Which stages of drug discovery do your biology services support?
Our biology services support multiple stages of drug discovery, including target validation, hit identification, hit confirmation, hit-to-lead, lead optimization, mechanism-of-action studies, and translational biology programs.
6. Which therapeutic areas does PozeSCAF support?
PozeSCAF supports drug discovery programs across multiple therapeutic areas through integrated biology, chemistry, and AI-driven discovery workflows. Specific therapeutic area expertise continues to expand based on client programs and internal research initiatives.
7. Why choose PozeSCAF for in vitro biology services?
PozeSCAF combines experimental biology with artificial intelligence, computational chemistry, medicinal chemistry, and synthetic chemistry within a unified drug discovery platform. This integrated approach helps accelerate project timelines, improve data-driven decision-making, and support efficient lead optimization.
8. How can I start an in vitro biology project with PozeSCAF?
Contact our scientific team to discuss your research objectives, target biology, assay requirements, and project timeline. We will work with you to develop a customized biology strategy aligned with your drug discovery goals.
Ready to Advance Your Drug Discovery Program?
Partner with PozeSCAF’s multidisciplinary biology, chemistry, and AI teams to accelerate target identification, target validation, hit identification, and lead optimization.